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Nutritional study with APUXAN

The nutritional effect of APUXAN was reviewed in a randomised, double-blind and placebo-controlled clinical trial on common colds. For this purpose, 104 subjects were given APUXAN or a placebo for 16 weeks. The selected subjects had an increased tendency for common colds with more than 3 common cold episodes in the last 12 months.

It has been shown that APUXAN has a nutritional significance for the stimulation of the immune system as it can significantly stimulate the immune system compared to placebo.

In the case of a cold episode, the immune system is better activated with APUXAN than in the comparison group.


Results of the nutritional study with APUXAN

At flu-like infections, T killer cells (cytotoxic T cells) are especially important. They are activated by macrophages and deliberately act against virus-infected cells. The number of T killer cells should increase in an effective immune response. However, a fundamental increase is associated with risks for the body. Therefore, regulatory T cells keep the formation of T killer cells under control. The quotient of cytotoxic and regulatory T cells describes the ratio between the two cell types. In a healthy state, the ratio should be balanced and only change in case of infection in favour of T killer cells, i.e. the quotient cytotoxic/regulatory T cells should increase. The placebo-controlled clinical study demonstrated that APUXAN supported the immune response of the T cells during a cold episode.

If there is no cold episode, the quotient cytotoxic/regulatory T cells is approximately equal in the placebo and APUXAN-treated groups. APUXAN keeps the immune system balanced.

In the case of a cold episode, the quotient cytotoxic/regulatory T cells in the APUXAN-group (blue bar) was significantly higher compared with the placebo group (grey bars) increases (see right-hand bar in the figure). That is to say, more T killer cells were activated and can act more quickly and efficiently against the infection.

With its influence on the T cell balance, APUXAN can support the immune system in combating infections.